Type 3 diabetes mellitus. The revival of inhaled insulin?

نویسندگان

  • Francesc Formiga
  • Manuel Pérez-Maraver
چکیده

Type 2 diabetes mellitus (DM) and dementia are two conditions highly prevalent today and probably interrelated. The term type 3 diabetes has therefore been proposed to try and provide a view integrating the potential pathogenetic mechanisms shared by DM and Alzheimer disease (AD). Significant epidemiological evidence relating DM and dementia has accumulated in the past decade. According to a recent complete meta-analysis, patients with DM have a relative risk of 1.46 of suffering AD. A greater impact of diabetes on dementia has been reported in people who also have a genetic predisposition, and also when diabetes is diagnosed earlier in life. Impact is lower in older groups, but diabetes continues to be a risk factor even in people aged 85 years. It should be noted that current epidemiological studies were not especially designed to assess the relationship between diabetes and dementia, and have therefore some limitations which are expected to be solved with future evidence from the Edinburgh Type 2 Diabetes Study. Various hypotheses have been proposed to explain the relationship between DM and dementia, from the effect of acute hyperglycemia itself (which may affect working

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عنوان ژورنال:
  • Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion

دوره 61 4  شماره 

صفحات  -

تاریخ انتشار 2014